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Article

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs.

Orphanet journal of rare diseases - 21 Sept 2022

Maekawa Hirotsugu, Jin Yonghui, Nishio Megumi, Kawai Shunsuke, Nagata Sanae, Kamakura Takeshi, Yoshitomi Hiroyuki, Niwa Akira, Saito Megumu K, Matsuda Shuichi, Toguchida Junya

Abstract excerpt

BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive heterotopic ossification (HO) in soft tissues due to a heterozygous mutation of the ACVR1A gene (FOP-ACVR1A), which erroneously transduces the BMP signal by Activin-A. Although inflammation is known to trigger HO in FOP, the role of FOP-ACVR1A on inflammatory cells remains to be elucidated. RESULTS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36131296
DOI: 10.1186/s13023-022-02506-3
PMCID: PMC9494870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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