Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis.

Nature cell biology - 1 Jun 2017

Decker Matthew, Martinez-Morentin Leticia, Wang Guannan, Lee Yeojin, Liu Qingxue, Leslie Juliana, Ding Lei

Abstract excerpt

Bone marrow fibrosis is a critical component of primary myelofibrosis (PMF). However, the origin of the myofibroblasts that drive fibrosis is unknown. Using genetic fate mapping we found that bone marrow leptin receptor (Lepr)-expressing mesenchymal stromal lineage cells expanded extensively and were the fibrogenic cells in PMF. These stromal cells downregulated the expression of key...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Imatinib Mesylate
Share to Myofibroblasts
Share to Osteogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Primary Myelofibrosis

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Receptors, Leptin

Share to Stem Cell Niche

Share to Thrombopoietin

Source

Open in PubMed Open full text

Identifiers

PMID: 28481328
DOI: 10.1038/ncb3530
PMCID: PMC5801040

Genes

PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis.PMID 28481328Read ↗

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis.Semantic proximity Read ↗

Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populationsSemantic proximity Read ↗

Understanding the origin, activation and regulation of matrix‐producing myofibroblasts for treatment of fibrotic diseaseSemantic proximity Read ↗

Regional specialization and fate specification of bone stromal cells in skeletal developmentSemantic proximity Read ↗

The role of the extracellular matrix in primary myelofibrosis.Semantic proximity Read ↗

Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies.Semantic proximity Read ↗

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cellsSemantic proximity Read ↗

Oncodevelopmental plasticity of the skeleton in myeloid neoplasmsSemantic proximity Read ↗

Inhibition of the EBF1-ITGB8 Axis in Bone Marrow Niche Ameliorates Hallmarks of MyelofibrosisSemantic proximity Read ↗

PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylationSemantic proximity Read ↗

Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice.Semantic proximity Read ↗

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.