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Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

12 May 2022

Abstract excerpt

In bone marrow, special microenvironments, known as niches, are essential for the maintenance of hematopoietic stem cells (HSCs). A population of mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells or leptin receptor-expressing cells are the major cellular component of HSC niches. The molecular regulation of HSC niche properties is not fully understood. The role of Runx...

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PMID: 35551452
DOI: 10.1038/s41467-022-30266-y

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