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Article

Hepatic Nfe2l2 Is Not an Essential Mediator of the Metabolic Phenotype Produced by Dietary Methionine Restriction.

Nutrients - 24 May 2021

Fang Han, Stone Kirsten P, Ghosh Sujoy, Forney Laura A, Sims Landon C, Vincik LeighAnn, Gettys Thomas W

Abstract excerpt

The principal sensing of dietary methionine restriction (MR) occurs in the liver, where it activates multiple transcriptional programs that mediate various biological components of the response. Hepatic Fgf21 is a key target and essential endocrine mediator of the metabolic phenotype produced by dietary MR. The transcription factor, Nfe2l2, is also activated by MR and functions in tandem with hepatic Atf4 to...

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Identifiers

PMID: 34073838
DOI: 10.3390/nu13061788
PMCID: PMC8225036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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