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Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights

15 Jun 2019

Abstract excerpt

Dietary sulfur amino acid restriction, also referred to as methionine restriction, increases food intake and energy expenditure and alters body composition in rodents, resulting in improved metabolic health and a longer lifespan. Among the known nutrient-responsive signaling pathways, the evolutionary conserved integrated stress response (ISR) is a lesser-understood candidate in mediating the hormetic effects of...

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PMID: 31208042
DOI: 10.3390/nu11061349

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