Article
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.
The Journal of clinical investigation - 1 Sept 2016
Maida Adriano, Zota Annika, Sjøberg Kim A, Schumacher Jonas, Sijmonsma Tjeerd P, Pfenninger Anja, Christensen Marie M, Gantert Thomas, Fuhrmeister Jessica, Rothermel Ulrike, Schmoll Dieter, Heikenwälder Mathias, Iovanna Juan L, Stemmer Kerstin, Kiens Bente, Herzig Stephan, Rose Adam J
Abstract excerpt
Dietary protein intake is linked to an increased incidence of type 2 diabetes (T2D). Although dietary protein dilution (DPD) can slow the progression of some aging-related disorders, whether this strategy affects the development and risk for obesity-associated metabolic disease such as T2D is unclear. Here, we determined that DPD in mice and humans increases serum markers of metabolic health. In lean mice, DPD...
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