Article

FGF21 deletion mildly exacerbates hepatic dysfunction in MASH diet and alcohol fed rats

2024-03-11

Abstract excerpt

<h4>Objective</h4> Fibroblast growth factor 21 (FGF21) is a hepatokine that improves dyslipidemia, steatosis, inflammation, and fibrosis. FGF21 analogues are in clinical development as treatments for metabolic and alcohol-associated liver disease, creating a need for new models to help understand FGF21 physiology and drug mechanisms of action. The aim of this study was to create and initially characterize the fir...

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Literature Corpus work: cbf5079b-b10d-5832-83db-7a327507e3b4
DOI: 10.1101/2024.03.06.583704

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