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Article

Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice.

Diabetes - 1 Oct 2011

Chartoumpekis Dionysios V, Ziros Panos G, Psyrogiannis Agathoklis I, Papavassiliou Athanasios G, Kyriazopoulou Venetsana E, Sykiotis Gerasimos P, Habeos Ioannis G

Abstract excerpt

OBJECTIVE: Obesity is characterized by chronic oxidative stress. Fibroblast growth factor 21 (FGF21) has recently been identified as a novel hormone that regulates metabolism. NFE2-related factor 2 (Nrf2) is a transcription factor that orchestrates the expression of a battery of antioxidant and detoxification genes under both basal and stress conditions. The current study investigated the role of Nrf2 in a mouse...

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Source

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Identifiers

PMID: 21852674
DOI: 10.2337/db11-0112
PMCID: PMC3178292

Genes

FGF21
NFE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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