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Article

Contingency and chance erase necessity in the experimental evolution of ancestral proteins.

eLife - 1 Jun 2021

Xie Victoria Cochran, Pu Jinyue, Metzger Brian Ph, Thornton Joseph W, Dickinson Bryan C

Abstract excerpt

The roles of chance, contingency, and necessity in evolution are unresolved because they have never been assessed in a single system or on timescales relevant to historical evolution. We combined ancestral protein reconstruction and a new continuous evolution technology to mutate and select proteins in the B-cell lymphoma-2 (BCL-2) family to acquire protein-protein interaction specificities that occurred during...

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Source

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Identifiers

PMID: 34061027
DOI: 10.7554/eLife.67336
PMCID: PMC8282340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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