Article
Signals: tinkering with domains.
Science signaling - 14 Sept 2010
Bornberg-Bauer Erich
Abstract excerpt
Evolution reuses established modules. At the level of cell signaling, protein domains are used in many contexts to transfer different messages. A frequently occurring binding domain uses a structural scaffold to allow for sequence variation at critical sites without compromising structural stability. Even random mutations have a high chance of conferring a novel function, and only a small fraction of available...
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