Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Time-lapse imaging of molecular evolution by high-throughput sequencing.

Nucleic acids research - 6 Sept 2018

Nguyen Quang Nam, Bouvier Clément, Henriques Adrien, Lelandais Benoit, Ducongé Frédéric

Abstract excerpt

High-throughput sequencing of in vitro selection could artificially provide large quantities of relic sequences from known times of molecular evolution. Here, we demonstrate how it can be used to reconstruct an empirical genealogical evolutionary (EGE) tree of an aptamer family. In contrast to classical phylogenetic trees, this tree-diagram represents proliferation and extinction of sequences within a population...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aptamers, Nucleotide
Share to Cell Proliferation
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Fitness

Share to High-Throughput Nucleotide Sequencing

Share to MCF-7 Cells

Share to Selection, Genetic

Share to Time-Lapse Imaging

Source

Open in PubMed Open full text

Identifiers

PMID: 29982617
DOI: 10.1093/nar/gky583
PMCID: PMC6125620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Time-lapse imaging of molecular evolution by high-throughput sequencing.PMID 29982617Read ↗

Contingency and chance erase necessity in the experimental evolution of ancestral proteins.Semantic proximity Read ↗

Deep distributed computing to reconstruct extremely large lineage trees.Semantic proximity Read ↗

AMaLa: Analysis of Directed Evolution Experiments via Annealed Mutational Approximated Landscape.Semantic proximity Read ↗

Diverse evolutionary trajectories characterize a community of RNA-cleaving deoxyribozymes: a case study into the population dynamics of in vitro selection.Semantic proximity Read ↗

Strategies for resolving cellular phylogenies from sequential lineage tracing data.Semantic proximity Read ↗

Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen.Semantic proximity Read ↗

Identifying high-affinity aptamer ligands with defined cross-reactivity using high-throughput guided systematic evolution of ligands by exponential enrichment.Semantic proximity Read ↗

Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery.Semantic proximity Read ↗

IMPATIENT-qPCR: melting-temperature-shift based evolution monitoring of successful aptamer development in SELEX processesSemantic proximity Read ↗

Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition.Semantic proximity Read ↗

Evolution in vitro: analysis of a lineage of ribozymes.Semantic proximity Read ↗

Mass trees: a new phylogenetic approach and algorithm to chart evolutionary history with mass spectrometry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.