Article
Reconstructing Ancient Proteins to Understand the Causes of Structure and Function.
Annual review of biophysics - 22 May 2017
Hochberg Georg K A, Thornton Joseph W
Abstract excerpt
A central goal in biochemistry is to explain the causes of protein sequence, structure, and function. Mainstream approaches seek to rationalize sequence and structure in terms of their effects on function and to identify function's underlying determinants by comparing related proteins to each other. Although productive, both strategies suffer from intrinsic limitations that have left important aspects of many...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.