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Article

Estimating the rate of irreversibility in protein evolution.

Genome biology and evolution - 1 Jan 2012

Soylemez Onuralp, Kondrashov Fyodor A

Abstract excerpt

Whether or not evolutionary change is inherently irreversible remains a controversial topic. Some examples of evolutionary irreversibility are known; however, this question has not been comprehensively addressed at the molecular level. Here, we use data from 221 human genes with known pathogenic...

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Identifiers

PMID: 23132897
DOI: 10.1093/gbe/evs096
PMCID: PMC3542581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23132897-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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