Article
Gene evolution and drug discovery.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006
McInerney James O, Finnerty Caroline S, Commins Jennifer M, Philip Gayle K
Abstract excerpt
Mutation and selection are the principle forces governing gene and protein sequence. Mutation is the major source of variation, and selection removes variation. Although many mutations are likely to be neutral with respect to natural selection, much of the extant sequence that is functionally important has experienced selective pressures in the past. By examining the history of DNA sequences, we can infer the...
Topics
- Animals
- Drug Design
- Evolution, Molecular
- Genetic Variation
- Mutation
- Phylogeny
- Selection, Genetic
- Sequence Analysis, DNA
- Sequence Analysis, Protein
- Transcription Factors