Tracing ancestral specificity of lectins: ancestral sequence reconstruction method as a new approach in protein engineering.

Abstract excerpt

Protein evolution is a process of molecular design leading to the diversity of functional proteins found in nature. Recent advances in bioinformatics and structural biology, in addition to recombinant protein expression techniques, enable us to analyze more directly the molecular evolution of proteins by a new method using ancestral sequence reconstruction (ASR), the so-called experimental molecular archaeology....

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