Article
Toward more accurate ancestral protein genotype-phenotype reconstructions with the use of species tree-aware gene trees.
Molecular biology and evolution - 1 Jan 2015
Groussin Mathieu, Hobbs Joanne K, Szöllősi Gergely J, Gribaldo Simonetta, Arcus Vickery L, Gouy Manolo
Abstract excerpt
The resurrection of ancestral proteins provides direct insight into how natural selection has shaped proteins found in nature. By tracing substitutions along a gene phylogeny, ancestral proteins can be reconstructed in silico and subsequently synthesized in vitro. This elegant strategy reveals the complex mechanisms responsible for the evolution of protein functions and structures. However, to date, all protein...
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