Article
Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios- Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals.
Frontiers in immunology - 1 Jan 2021
Zhang Yuyue, Zhang Jie, Shi Yun, Shen Min, Lv Hui, Chen Shu, Feng Yingjie, Chen Heng, Xu Xinyu, Yang Tao, Xu Kuanfeng
Abstract excerpt
CD4 Tregs are involved in the regulation of various autoimmune diseases but believed to be highly heterogeneous. Studies have indicated that Helios controls a distinct subset of functional Tregs. However, the immunological changes in circulating Helios+ and Helios- Tregs are not fully explored in type 1 diabetes (T1D). Here, we elucidated the differences in maturation status and immune regulatory phenotypes of...
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