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Helios characterized circulating follicular helper T cells with enhanced functional phenotypes and was increased in patients with systemic lupus erythematosus.

Clinical and experimental medicine - 19 Jan 2024

Zeng Xingyue, Alimu Xiayidan, Bahabayi Ayibaota, Zhang Zhonghui, Zheng Mohan, Yuan Zihang, Liu Tianci, Liu Chen

Abstract excerpt

Helios was related to the immunosuppressive capacity and stability of regulatory T cells. However, the significance of Helios in follicular help T (TFH) and follicular regulatory T (TFR) cells is unclear. This research aimed to clarify the significance of Helios (IKZF2) in TFH and TFR cells and its clinical value in systemic lupus erythematosus (SLE). IKZF2 mRNA in different cell subsets was analyzed. Helios+...

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Identifiers

PMID: 38240853
DOI: 10.1007/s10238-023-01289-6
PMCID: PMC10799143

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