Article

Abatacept treatment in LRBA deficient patients results in an increase in circulating FoxP3 <sup>+</sup> Helios <sup>+</sup> natural Treg

2024-02-13

Abstract excerpt

<h4>Background</h4> Mutations in the lipopolysaccharide-responsive beige-like anchor (LRBA) gene were identified to cause autoimmunity and immunodeficiency with a broad spectrum of clinical manifestations. Increased lysosomal degradation of the CTLA-4 due to the lack of recylcing by LRBA protein has been described resulting in a reduced suppressive capacity of regulatory T cells (Treg). <h4>>Objective</h4> We so...

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Literature Corpus work: c4f540b0-d730-54ef-8774-28086638df1d
DOI: 10.1101/2024.02.10.579765

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