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Article

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

Journal of autoimmunity - 1 Jul 2016

Buckner Jane H, Nepom Gerald T

Abstract excerpt

Autoreactive lymphocytes display a programmed set of characteristic effector functions and phenotypic markers that, in combination with antigen-specific profiling, provide a detailed picture of the adaptive immune response in Type 1 diabetes (T1D). The CD4+ T cell effector compartment (referred to as "Teff" in this article) has been extensively analyzed, particularly because the HLA genes most strongly associated...

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Identifiers

PMID: 26948997
DOI: 10.1016/j.jaut.2016.02.009
PMCID: PMC4903876

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