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Article

Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.

The Journal of biological chemistry - 1 Jul 2021

Absmeier Eva, Vester Karen, Ghane Tahereh, Burakovskiy Dmitry, Milon Pohl, Imhof Petra, Rodnina Marina V, Santos Karine F, Wahl Markus C

Abstract excerpt

Brr2 is an essential Ski2-like RNA helicase that exhibits a unique structure among the spliceosomal helicases. Brr2 harbors a catalytically active N-terminal helicase cassette and a structurally similar but enzymatically inactive C-terminal helicase cassette connected by a linker region. Both cassettes contain a nucleotide-binding pocket, but it is unclear whether nucleotide binding in these two pockets is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34048711
DOI: 10.1016/j.jbc.2021.100829
PMCID: PMC8220420

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