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Article

The human branchpoint-interacting stem-loop sequence and structure regulates U2 snRNA expression, branchpoint recognition, and the transcriptome.

Nucleic acids research - 19 Mar 2026

Stevers Meredith B, Katzman Sol, Jurica Melissa S

Abstract excerpt

During pre-mRNA splicing, the branch helix forms when U2 snRNP engages with introns to initiate spliceosome assembly. The branch helix is mutually exclusive with the U2 snRNA branchpoint-interacting stem loop (BSL). In yeast, BSL alteration affects branchpoint recognition, but its role in human cells, where branchpoint usage is more flexible, is unknown. To examine the impact of perturbing BSL base pairing, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41885209
DOI: 10.1093/nar/gkag245
PMCID: PMC13019295

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The human branchpoint-interacting stem-loop sequence and structure regulates U2 snRNA expression, branchpoint recognition, and the transcriptome.PMID 41885209Read ↗

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