Article
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.
Science (New York, N.Y.) - 5 Jul 2013
Mozaffari-Jovin Sina, Wandersleben Traudy, Santos Karine F, Will Cindy L, Lührmann Reinhard, Wahl Markus C
Abstract excerpt
The Ski2-like RNA helicase Brr2 is a core component of the spliceosome that must be tightly regulated to ensure correct timing of spliceosome activation. Little is known about mechanisms of regulation of Ski2-like helicases by protein cofactors. Here we show by crystal structure and biochemical analyses that the Prp8 protein, a major regulator of the spliceosome, can insert its C-terminal tail into Brr2's...
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