Article
Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.
Molecular cell - 28 Aug 2009
Pena Vladimir, Jovin Sina Mozaffari, Fabrizio Patrizia, Orlowski Jerzy, Bujnicki Janusz M, Lührmann Reinhard, Wahl Markus C
Abstract excerpt
Brr2 is a unique DExD/H box protein required for catalytic activation and disassembly of the spliceosome. It contains two tandem helicase cassettes that both comprise dual RecA-like domains and a noncanonical Sec63 unit. The latter may bestow the enzyme with unique properties. We have determined crystal structures of the C-terminal Sec63 unit of yeast Brr2, revealing three domains, two of which resemble...
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