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Article

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

Nature structural & molecular biology - 1 Apr 2011

Williams Gareth J, Williams R Scott, Williams Jessica S, Moncalian Gabriel, Arvai Andrew S, Limbo Oliver, Guenther Grant, SilDas Soumita, Hammel Michal, Russell Paul, Tainer John A

Abstract excerpt

The Rad50 ABC-ATPase complex with Mre11 nuclease is essential for dsDNA break repair, telomere maintenance and ataxia telangiectasia-mutated kinase checkpoint signaling. How Rad50 affects Mre11 functions and how ABC-ATPases communicate nucleotide binding and ligand states across long distances and among protein partners are questions that have remained obscure. Here, structures of Mre11-Rad50 complexes define the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21441914
DOI: 10.1038/nsmb.2038
PMCID: PMC3118400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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