Article
An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase.
Nucleic acids research - 16 Nov 2016
Windgassen Tricia A, Keck James L
Abstract excerpt
Helicases couple ATP hydrolysis to nucleic acid binding and unwinding via molecular mechanisms that remain poorly defined for most enzyme subfamilies within the superfamily 2 (SF2) helicase group. A crystal structure of the PriA SF2 DNA helicase, which governs restart of prematurely terminated replication processes in bacteria, revealed the presence of an aromatic-rich loop (ARL) on the presumptive DNA-binding...
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