Article
Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice.
PLoS computational biology - 1 May 2021
Ralph Martin R, Shi Shu-Qun, Johnson Carl H, Houdek Pavel, Shrestha Tenjin C, Crosby Priya, O'Neill John S, Sládek Martin, Stinchcombe Adam R, Sumová Alena
Abstract excerpt
Modification of the Per2 clock gene in mPer2Luc reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodality, enhanced phase resetting to light pulses, and altered entrainment to scheduled feeding. Mechanistic mathematical modelling predicts that enhanced protein...
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