Article
PER1 phosphorylation specifies feeding rhythm in mice.
Cell reports - 12 Jun 2014
Liu Zhiwei, Huang Moli, Wu Xi, Shi Guangsen, Xing Lijuan, Dong Zhen, Qu Zhipeng, Yan Jie, Yang Ling, Panda Satchidananda, Xu Ying
Abstract excerpt
Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS). Although the paralogous phosphorylation site S714 in PER1 is conserved in mice, its specific function in circadian organization remains unknown. Here, we find that the PER1S714G mutation accelerates the molecular feedback loop....
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