Article
Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.
Neuron - 1 May 2001
Bae K, Jin X, Maywood E S, Hastings M H, Reppert S M, Weaver D R
Abstract excerpt
The role of mPer1 and mPer2 in regulating circadian rhythms was assessed by disrupting these genes. Mice homozygous for the targeted allele of either mPer1 or mPer2 had severely disrupted locomotor activity rhythms during extended exposure to constant darkness. Clock gene RNA rhythms were blunted in the suprachiasmatic nucleus of mPer2 mutant mice, but not of mPER1-deficient mice. Peak mPER and mCRY1 protein...
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