Endogenous circadian reporters reveal critical consequences of diverse novel mutations in clock genes

Abstract excerpt

Adverse consequences from having a faulty circadian clock include compromised sleep quality and poor performance in the short-term, and metabolic diseases and cancer in the long-term. However, our understanding of circadian disorders is limited by the incompleteness of our molecular models and our dearth of defined mutant models. Because it would be prohibitively expensive to develop live animal models to study th...

Topics

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• Cloning, Molecular
• Mice
• Mice, Transgenic
• Models, Biological
• Mutation
• Nuclear Proteins
• Phenotype
• Transcription Factors

Identifiers and source

Literature Corpus work

6ea8e0b0-89f0-51ea-807d-fff6a7d256ec

DOI

10.21203/rs.3.rs-1842192/v1