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Article

Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.

Nature communications - 12 Jun 2019

Doi Masao, Shimatani Hiroyuki, Atobe Yuta, Murai Iori, Hayashi Hida, Takahashi Yukari, Fustin Jean-Michel, Yamaguchi Yoshiaki, Kiyonari Hiroshi, Koike Nobuya, Yagita Kazuhiro, Lee Choogon, Abe Manabu, Sakimura Kenji, Okamura Hitoshi

Abstract excerpt

Non-coding cis-regulatory elements are essential determinants of development, but their exact impacts on behavior and physiology in adults remain elusive. Cis-element-based transcriptional regulation is believed to be crucial for generating circadian rhythms in behavior and physiology. However, genetic evidence supporting this model is based on mutations in the protein-coding sequences of clock genes. Here, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31189882
DOI: 10.1038/s41467-019-10532-2
PMCID: PMC6561950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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