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Article

Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.

Genes & development - 1 Jun 2003

Oster Henrik, Baeriswyl Stephanie, Van Der Horst Gijsbertus T J, Albrecht Urs

Abstract excerpt

The mPer1, mPer2, mCry1, and mCry2 genes play a central role in the molecular mechanism driving the central pacemaker of the mammalian circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus. In vitro studies suggest a close interaction of all mPER and mCRY proteins. We investigated mPER and mCRY interactions in vivo by generating different combinations of mPer/mCry double-mutant mice. We...

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Identifiers

PMID: 12782655
DOI: 10.1101/gad.256103
PMCID: PMC196069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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