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Article

Structural consequences of nucleophosmin mutations in acute myeloid leukemia.

The Journal of biological chemistry - 22 Aug 2008

Grummitt Charles G, Townsley Fiona M, Johnson Christopher M, Warren Alan J, Bycroft Mark

Abstract excerpt

Mutations affecting NPM1 (nucleophosmin) are the most common genetic lesions found in acute myeloid leukemia (AML). NPM1 is one of the most abundant proteins found in the nucleolus and has links to the MDM2/p53 tumor suppressor pathway. A distinctive feature of NPM1 mutants in AML is their aberrant localization to the cytoplasm of leukemic cells. This mutant phenotype is the result of the substitution of several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18511415
DOI: 10.1074/jbc.M801706200
PMCID: PMC2516977

Genes

NPM1
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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