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Genome-wide association study of multiple neuropathology endophenotypes identifies novel risk loci and provides insights into known Alzheimer’s risk loci

2022-12-14

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease is highly heritable and exhibits neuropathological hallmarks of neurofibrillary tau tangles and neuritic amyloid plaques. Previous genome-wide association studies (GWAS) have identified over 70 genomic risk loci of clinically diagnosed Alzheimer’s disease. However, upon autopsy, many Alzheimer’s disease patients have multiple comorbid neuropathologies that may have independe...

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Literature Corpus work
736d4f42-dee9-5242-be38-37b2f991f0af
DOI
10.1101/2022.12.13.22282475
Open publication

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Genome-wide association study of multiple neuropathology endophenotypes identifies novel risk loci and provides insights into known Alzheimer’s risk lociDOI 10.1101/2022.12.13.22282475
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