Article
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.
Acta neuropathologica - 1 Aug 2010
Thal Dietmar Rudolf, Papassotiropoulos Andreas, Saido Takaomi C, Griffin W Sue T, Mrak Robert E, Kölsch Heike, Del Tredici Kelly, Attems Johannes, Ghebremedhin Estifanos
Abstract excerpt
The deposition of amyloid beta-protein (Abeta) in the vessel wall, i.e., cerebral amyloid angiopathy (CAA), is associated with Alzheimer's disease (AD). Two types of CAA can be differentiated by the presence or absence of capillary Abeta-deposits. In addition, as in Alzheimer's disease, risk for capillary CAA is associated with the apolipoprotein E (APOE) epsilon4-allele. Because these morphological and genetic...
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