Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis

Abstract excerpt

The presence of functional brown adipose tissue in humans is known to be associated with cardiovascular health. Here, we show that adipocyte-specific deletion of the RNA binding protein HuR, which we have previously shown to reduce BAT-mediated thermogenesis, is sufficient to mediate a spontaneous development of cardiac hypertrophy and fibrosis. These results may have implications on the mechanisms by which BAT...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adipose Tissue and Metabolism
• Share to Cardiovascular Disease and Adiposity
• Share to Cardiovascular Effects of Exercise