Article

Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR

2025-05-23

Abstract excerpt

<h4>ABSTRACT</h4> RNA binding proteins (RBPs) play essential roles in all major steps of RNA processing. Genetic studies in human and mouse models support that many RBPs are crucial for maintaining homeostasis in key tissues/organs, but to what extent the function of RBPs is conserved between humans and mice is not clear. Our recent study using a chimeric humanized liver mouse model found that knocking down human...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37263234-4043-5ab1-a254-f7d411791614
DOI: 10.1101/2025.05.22.655551

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuRDOI 10.1101/2025.05.22.655551Read

RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expressionSemantic proximity Read

A long non-coding RNA,<i>APOA4</i>-AS, regulates<i>APOA4</i>expression depending on HuR in miceSemantic proximity Read

Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver diseaseSemantic proximity Read

Adipocyte deletion of the RNA binding protein HuR induces cardiac hypertrophy and fibrosisSemantic proximity Read

Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptorSemantic proximity Read

Emerging roles of RNA-binding proteins in fatty liver disease.Semantic proximity Read

Suppression of hepatic amino acid catabolism by the human-specific lncRNA hLMR1Semantic proximity Read

Saturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR).Semantic proximity Read

Single-cell analysis of non-alcoholic fatty livers identifies a role for the constitutive androstane receptorSemantic proximity Read

Multilevel integrative transcriptome analyses in humans and humanized mice define in vivo human lncRNA metabolic regulatorsSemantic proximity Read

Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptorSemantic proximity Read

Disrupted Post-Transcriptional Regulation of Gene Expression as A Hallmark of Fatty Liver ProgressionSemantic proximity Read