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Article

The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development.

Molecular and cellular biology - 1 May 2009

Katsanou Vicky, Milatos Stavros, Yiakouvaki Anthie, Sgantzis Nikos, Kotsoni Anastasia, Alexiou Maria, Harokopos Vaggelis, Aidinis Vassilis, Hemberger Myriam, Kontoyiannis Dimitris L

Abstract excerpt

HuR is an RNA-binding protein implicated in a diverse array of pathophysiological processes due to its effects on the posttranscriptional regulation of AU- and U-rich mRNAs. Here we reveal HuR's requirement in embryonic development through its genetic ablation. Obligatory HuR-null embryos exhibited a stage retardation phenotype and failed to survive beyond midgestation. By means of conditional transgenesis, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19307312
DOI: 10.1128/MCB.01393-08
PMCID: PMC2682039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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