Article
Atrial natriuretic peptide orchestrates a coordinated physiological response to fuel non shivering thermogenesis
2019-12-06
Abstract excerpt
Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and arterial pressure in mammals. It is unclear whether and how ANP controls cold-induced thermogenesis in vivo . Here we show that acute cold exposure induces cardiac ANP secretion in mice and humans. Genetic inactivation of ANP promotes cold intolerance and suppresses about half of cold-induced brown adipose tissue (BAT) activation i...
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Identifiers and source
- Literature Corpus work
- a88d792a-1c51-524d-a372-d39dfcd32543
- DOI
- 10.1101/866277