Article
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.
The Journal of clinical investigation - 1 Mar 2012
Bordicchia Marica, Liu Dianxin, Amri Ez-Zoubir, Ailhaud Gerard, Dessì-Fulgheri Paolo, Zhang Chaoying, Takahashi Nobuyuki, Sarzani Riccardo, Collins Sheila
Abstract excerpt
The ability of mammals to resist body fat accumulation is linked to their ability to expand the number and activity of "brown adipocytes" within white fat depots. Activation of β-adrenergic receptors (β-ARs) can induce a functional "brown-like" adipocyte phenotype. As cardiac natriuretic peptides (NPs) and β-AR agonists are similarly potent at stimulating lipolysis in human adipocytes, we investigated whether NPs...
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