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Article

Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence.

Molecular and cellular biology - 1 Sept 2001

Wang W, Yang X, Cristofalo V J, Holbrook N J, Gorospe M

Abstract excerpt

Cellular aging is accompanied by alterations in gene expression patterns. Here, using two models of replicative senescence, we describe the influence of the RNA-binding protein HuR in regulating the expression of several genes whose expression decreases during senescence. We demonstrate that HuR levels, HuR binding to target mRNAs encoding proliferative genes, and the half-lives of such mRNAs are lower in...

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Identifiers

PMID: 11486028
DOI: 10.1128/MCB.21.17.5889-5898.2001
PMCID: PMC87308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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