Article

HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in brown adipocytes

2024-10-24

Abstract excerpt

Several uncoupling protein 1 (UCP1)-independent thermogenic pathways have been described in thermogenic adipose tissue, including calcium-mediated thermogenesis in beige adipocytes via sarco/endoplasmic reticulum ATPase (SERCA). We have previously shown that adipocyte-specific deletion of the RNA binding protein human antigen R (HuR) results in thermogenic dysfunction independent of UCP1 expression. RNA sequencing...

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Literature Corpus work: e6e26929-d65a-5c81-9ba3-eedc5a05ded9
DOI: 10.1101/2024.10.22.619637

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