Article

HuR inhibition reduces post-ischemic cardiac remodeling by dampening acute inflammatory gene expression and the innate immune response

2023-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Myocardial ischemia/reperfusion (I/R) injury and the resulting cardiac remodeling is a common cause of heart failure. The RNA binding protein Human Antigen R (HuR) has been previously shown to reduce cardiac remodeling following both I/R and cardiac pressure overload, but the full extent of the HuR-dependent mechanisms within cells of the myocardium have yet to be elucidated. In this study, we a...

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Literature Corpus work: 8f53d276-729d-5adc-921f-5bd5bc6b9afd
DOI: 10.1101/2023.01.17.524420

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