Article
The impact of chromosomal fusions on 3D genome folding and recombination in the germ line.
Nature communications - 20 May 2021
Vara Covadonga, Paytuví-Gallart Andreu, Cuartero Yasmina, Álvarez-González Lucía, Marín-Gual Laia, Garcia Francisca, Florit-Sabater Beatriu, Capilla Laia, Sanchéz-Guillén Rosa Ana, Sarrate Zaida, Aiese Cigliano Riccardo, Sanseverino Walter, Searle Jeremy B, Ventura Jacint, Marti-Renom Marc A, Le Dily François, Ruiz-Herrera Aurora
Abstract excerpt
The spatial folding of chromosomes inside the nucleus has regulatory effects on gene expression, yet the impact of genome reshuffling on this organization remains unclear. Here, we take advantage of chromosome conformation capture in combination with single-nucleotide polymorphism (SNP) genotyping and analysis of crossover events to study how the higher-order chromatin organization and recombination landscapes...
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