Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

11 Mar 2018

Abstract excerpt

BACKGROUND: Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. MAIN BODY: The dominant interest in telomerase results from its role in cancer. The role of telomeres and telomere maintenance mechanisms is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics and Chromatin Dynamics
Share to Nuclear Structure and Function
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29526163
DOI: 10.1186/s12929-018-0422-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancerPMID 29526163Read ↗

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new playersSemantic proximity Read ↗

Telomerase Regulation: A Role for EpigeneticsSemantic proximity Read ↗

Current Insights to Regulation and Role of Telomerase in Human DiseasesSemantic proximity Read ↗

TERT—Regulation and Roles in Cancer FormationSemantic proximity Read ↗

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in LeukemiaSemantic proximity Read ↗

Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with EpigeneticsSemantic proximity Read ↗

Telomerase in Cancer: Function, Regulation, and Clinical TranslationSemantic proximity Read ↗

Telomeres and telomerase in oncogenesis (Review)Semantic proximity Read ↗

Telomere Maintenance Mechanisms in CancerSemantic proximity Read ↗

Role of telomerase in the tumour microenvironmentSemantic proximity Read ↗

Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A ReviewSemantic proximity Read ↗

Human telomerase expression regulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.