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Article

Mir‐23a induces telomere dysfunction and cellular senescence by inhibiting <scp>TRF</scp>2 expression

6 Mar 2015

Abstract excerpt

Telomeric repeat binding factor 2 (TRF2) is essential for telomere maintenance and has been implicated in DNA damage response and aging. Telomere dysfunction induced by TRF2 inhibition can accelerate cellular senescence in human fibroblasts. While previous work has demonstrated that a variety of factors can regulate TRF2 expression transcriptionally and post-translationally, whether microRNAs (miRNAs) also...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 25753893
DOI: 10.1111/acel.12304

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