Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

Abstract excerpt

High-grade astrocytoma of WHO grade 4 termed glioblastoma multiforme (GBM) is a common human brain tumor with poor patient outcome. Astrocytoma demonstrates two known telomere maintenance mechanisms (TMMs) based on telomerase activity (TA) and on alternative lengthening of telomeres (ALT). ALT is associated with lower tumor grades and better outcome. In contrast to ALT, regulation of TA in tumors by direct...

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• Share to Epigenetics and DNA Methylation
• Share to Mitochondrial Function and Pathology
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