Article
Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop.
Circulation research - 8 Jan 2021
Papa Arianne, Kushner Jared, Hennessey Jessica A, Katchman Alexander N, Zakharov Sergey I, Chen Bi-Xing, Yang Lin, Lu Ree, Leong Stephen, Diaz Johanna, Liu Guoxia, Roybal Daniel, Liao Xianghai, Del Rivero Morfin Pedro J, Colecraft Henry M, Pitt Geoffrey S, Clarke Oliver, Topkara Veli, Ben-Johny Manu, Marx Steven O
Abstract excerpt
RATIONALE: Changing activity of cardiac CaV1.2 channels under basal conditions, during sympathetic activation, and in heart failure is a major determinant of cardiac physiology and pathophysiology. Although cardiac CaV1.2 channels are prominently upregulated via activation of PKA (protein kinase A), essential molecular details remained stubbornly enigmatic. OBJECTIVE: The primary goal of this study was to...
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