Article
Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions.
Clinical pharmacology and therapeutics - 1 Mar 2011
Johnson J A, Liggett S B
Abstract excerpt
G-protein-coupled receptors (GPCRs) are the targets for many drugs, and genetic variation in coding and noncoding regions is apparent in many such receptors. In this superfamily, adrenergic receptors (ARs) were among the first in which single-nucleotide polymorphisms (SNPs) were discovered, and studies including in vitro mutagenesis, genetically modified mouse models, human ex vivo and in vitro studies and...
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