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Article

Requirement of the Ca2+ channel β2 subunit for sympathetic PKA phosphorylation.

Journal of pharmacological sciences - 1 Mar 2021

Murakami Manabu, Xu Feng, Ohba Takayoshi, Kobayashi Takeshi, Inoue Yoshiro, Murakami Agnieszka M, Miyoshi Ichiro, Ono Kyoichi, Tohse Noritsugu

Abstract excerpt

Facilitation of cardiac function in response to signals from the sympathetic nervous system is initiated by the phosphorylation of L-type voltage-dependent Ca2+ channels (VDCCs) by protein kinase A (PKA), which in turn is activated by β-adrenoceptors. Among the five subunits (α1, β, α2/δ, and γ) of VDCCs, the α1 subunit and the family of β subunits are substrates for PKA-catalyzed phosphorylation; however, the...

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Source

Identifiers

PMID: 33602505
DOI: 10.1016/j.jphs.2020.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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